There exists a release of norepinephrine from the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors from the dorsal horn to lower afferent discomfort transmission and produce analgesia. For that reason, medications like clonidine that target alpha-2 receptors can influence the transmission of discomfort. Applies to clonidine: oral pill, https://douglasq627jap2.wikicorrespondent.com/user