-dihydroxyphenyl rings of procyanidin C1 were found in the construction mimicking K2E2·Pi condition. This interaction triggers the ion pathway (which happens to be formed by residues which includes one of several interacting arginines, R979) to be inaccessible within the extracellular side76. This binding mode might thus sterically impede ion exchange. https://danteekorv.blogozz.com/29078663/the-definitive-guide-to-corticosterone